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The fifth interim analysis performed on December 2009 revealed that the difference in the eradication rates between the LAcR and CAR regimens was statistically significant (P = 0.014).
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There were no significant differences in the eradication rates for the different regimens when the setting (primary vs. secondary care) or endoscopic diagnosis were considered.
There were no obvious differences in the eradication rates of other organisms, albeit the number of isolates was generally small.
The results indicate that the difference in the estimated prevalence between eradication routes was not statistically significant.
The difference in eradication rates was 0.4% (−4% to 4%), and the 95% prediction intervals ranged from −14%to13%3% (supplementary figure E), with evidence of heterogeneity (I=55.3%; P=0.014).
The difference in eradication rates was −0.5% (−5% to 5%), and the 95% prediction intervals ranged from −16%to15%5% (supplementary figure C), with evidence of heterogeneity (I=61.1%; P=0.003).
The difference in eradication rates was 1.3% (−4% to 5%), and the 95% prediction intervals ranged from −11%to12%2% (supplementary figure D), with low heterogeneity (I=22.3%; P=0.272).
Results were expressed as relative risk for success of H pylori eradication and as difference in eradication rates among patients assigned to sequential therapy versus other eradication regimens.
The difference in eradication rates was 9.0% (4% to 14%), favouring sequential treatment, the 95% prediction intervals ranged from −9% to 26% (supplementary figure B), with evidence of heterogeneity (I=66.4%; P=0.000).
Although eradication of Helicobacter Pylori is both suggested in patient with duodenal ulcer scar or non-ulcer dyspepsia, the difference in eradication rate could provide us a better outcome predication to discuss with the patient.
The difference in eradication rates was 15% (13% to 18%) favouring sequential treatment, and the 95% prediction intervals ranged from 9% to 22% (supplementary figure A), with evidence of heterogeneity (I=34.0%; P=0.061).
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