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This likely occurs for trials both with and without visual feedback creating little difference in the endpoint variability between the two groups.
Although a major difference in the endpoint figures are seen between Blough et al.'s [ 4] data and Chung et al.'s [ 9] work, no difference exists between the data presented here and other figures.
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There may be differences in the endpoint of interest amongst individuals which are so large that it may be more appropriate to focus on a sub-group of the test species in order to detect changes caused by the tested stressor.
When the endpoint stiffness was examined there were some similarities and some differences in the endpoint stiffness between the two visual conditions.
This may reflect the heterogeneous medical conditions of the different populations studied, as well as differences in the endpoints and outcomes measure.
Non-inferiority to allopurinol was to be declared for febuxostat 40 mg if the value of the lower limit of the 95% CI for the difference in achieving the endpoint was greater than -10%.
This was considered to be the case when a statistical difference in the primary endpoint of a clinical trial was observed or, in the absence of a defined primary endpoint, when statistical differences were observed in several of the reported endpoints.
Differences in the endpoints driving classification were also observed between the RCD and NCD.
To obtain a significant difference in the primary endpoint 180 patients will be enrolled.
Finally, it is likely that the two studies were underpowered to demonstrate a difference in the principal endpoint.
The null hypothesis was that there would be no difference in the primary endpoint (mean time to PC90) between CPG−DDS alone and CPG−DDS plus artesunate at each of the three doses.
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CEO of Professional Science Editing for Scientists @ prosciediting.com