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As the ROLO Study did not find any difference in the birthweight [ 10] or adiposity measures except the aforementioned thigh circumference [ 46] of the neonates between intervention and control groups, this has facilitated follow-up analysis of the offspring as a cohort of healthy babies born to non-diabetic healthy mothers.
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Table 2 presents the influence of maternal characteristics on the birthweight of the infants as the difference in mean birthweight in relation to the maternal characteristics listed in each row.
There are only small differences in the mean birthweight between cases with and those without data on GA (table 3).
In the analyses, beta represents the difference in mean birthweight (continuous variable) for cigarette smoking between the variant genotype after adjustment for the selected effect modifiers.
The observed difference in mean birthweight at the population level of 200 g (ART children compared with all other births) is considerable, and equivalent to the effect of cigarette smoking (British Medical Association, 2004).
Table 3 presents the crude and adjusted combined associations of continuous maternal smoking during pregnancy and maternal GSTT1 and GSTM1 genotypes with reference to infant birthweight, where β represents the difference in mean birthweight between each subgroup and the reference group.
ß represent the difference in mean birthweight for maternal characteristics in each row.
We used linear regression with robust estimation variance to estimate the difference in mean birthweight among teenage mother groups compared with adult women.
Thirdly dichotomisation is used to provide estimates that are more clinically meaningful for example in comparing two groups when a difference in say, mean birthweight in two groups may be difficult to interpret while a difference in the proportion with low birthweight is intuitively more meaningful.
We found a small difference in birthweight between the groups, with a tendency for the children with missing data on gestational age being slightly heavier, though the distribution of birthweight or gestational age did not differ systematically between the two groups.
To detect a difference in mean birthweight of 100 g between the groups, a sample size of 211 for each group is needed.
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CEO of Professional Science Editing for Scientists @ prosciediting.com