Sentence examples for difference in replication from inspiring English sources
In fact, only 5.7% of the genome showed a difference in replication timing; 3.2% of the genome replicated later in LNCaP compared to PrEC (ΔWA < −25), and 2.5% replicated earlier in LNCaP compared to PrEC (ΔWA > 25) (Supplementary Figure 1g).
It has been observed that the difference in replication timing often corresponds to a different spatial localisation of DNA sequence in the nuclear architecture [1].
In addition, there is apparently no difference in replication of the hepatitis virus after acute Q fever hepatitis [ 14].
The outcome measure was the difference in replication kinetics of FHV-1 or HHV-1 comparing various lysine concentrations.
In contrast, the native and invasive strain showed no significant difference in replication in cultured mosquito, monkey or human cells.
It must be concluded that the difference in replication timing observed for these two chromosomal arms is therefore not due to different phylogenetic origins.
However, there was no difference in replication-licensed or proliferating cells between the two subgroups as assessed by Mcm2 (P = 0.87) or Ki67 (P = 0.77), respectively.
In a study comparing the growth properties of H5N1 of 3 different clades (2.3.2, 2.3.4 and 7), Sun et al.30 found significant differences in replication between H5N1 strains of different clades with the clade 2.3.4 replicating faster and to higher titer than the other viruses.
Expanding our modeling approach to H5N1 viruses of different clades could be useful to uncover differences in replication strategies for viruses of the same subtypes but with different potentials for human infections.
We demonstrate that genomic regions that undergo long-range epigenetic deregulation in cancer also show concordant differences in replication timing.
Strikingly, almost all the regions showing differences in replication profiles initially identified by visual inspection, were detected by the genome-wide analysis (Fig. 3 and Supplementary Figure S5).
