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However, CHWs in Kenya, who reported to be selected by the community, did not show any difference in guideline adherence when compared to CHWs who reported no community involvement in selection (Rowe et al. 2007a).
The difference in guideline use was not statistically significant in intention-to-treat analysis (55% vs. 48%; p = 0.081), but was significant in per-protocol analysis, i.e., PTs who participated in the implementation seminar reported frequent use of guidelines to significantly greater extent than those in the control group (63% vs. 48%; p = 0.043).
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As these changes were minor, the difference in guidelines from 2003 to 2013 does not have a significant effect the interpretation of the results.
Logistic regression analysis was conducted to evaluate differences in guideline adherence for male and female patients.
Differences in guideline recommendations are not sufficient to explain variation of prescribing among countries, thus other factors must be considered.
These differences in guideline adherence were mainly caused by significantly higher rates of guideline violations concerning chemotherapy in all the TNBC age groups (P < 0.001) (see Table 3).
The fact that we found large differences in guideline adherence between practices is also consistent with previous studies in diabetes care [ 17].
We did not find any differences in guideline adherence between GPs with a higher and those with a lower objective workload.
As in practice it will take some time before better guideline adherence results in improved health outcomes, we have to assume that differences in guideline adherence between practices are relatively constant over time.
In addition, due to the differences in guideline management of children under 13 years of age to adults with asthma [ 1], only data on patients ≥13 years of age were included in the analysis.
However, differences in guideline specifics, models of care and study design may have contributed to the varied outcomes observed in the studies and limited their ability to inform best clinical practice.
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