One explanation for the difference in efficacy between the treatments might be in the pathophysiological process of tendinopathy.
No difference in efficacy was recorded comparing patients suffering from CM from 5 up to 20 years.
No difference in efficacy was seen comparing CEN1 HC-Br and CEN1 HC, while the brominated variant had higher cytotoxicity.
The difference in efficacy is most likely due to the rapid initial rise in plasma level after subcutaneous administration [23].
This suggests that another mechanism for cytotoxicity must account for the difference in efficacy of the synthetic short-chain PIAs.
The complete response rate in the historical control group was 70% (40/57), showing no difference in efficacy.
The study concluded that both drugs showed a significant reduction in VAS scores while not showing a significant difference in efficacy and safety [65].
No obvious difference in efficacy was seen comparing CEN1 HC-Br and CEN1 HC, while the first peptide had higher cytotoxicity compared to the debrominated equivalent.
In the literature, no significant difference in efficacy and safety has been reported between preoperative and postoperative initiation of LMWH in HR and KR [1, 6, 7].
Conclusion: The present study revealed no significant difference in efficacy as in tolerance between original brand-name NIMBEX® and generic (CISATREX®) of cisatracurium.
One of the surprises from these tests is the difference in efficacy between the free and paid versions of Zone Alarm, one of the older personal firewalls around.
