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Indeed, the main performance gain of FACIL comes from the difference in database size that it queries.
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Firstly, the consensus is constrained by differences in database size.
Second, we designed all contingency analyses to account for differences in database sizes.
The database content statistics of the five databases (Table 2) already show that there are notable differences in database size.
When translating between databases, inherent differences in database structure, syntax and search algorithms need to be understood for optimal retrieval.
The same data sources were available in MB as in NL, with minor differences in database characteristics.
Differences in database reliability could be the result of the prospective or retrospective nature of the study.
Another analytical challenge in combining datasets of various species is to overcome species-specific residual variation in fold-change and substantial differences in database size.
However, the analysis provides a baseline for the within-country dimension of the monitoring and evaluation of the KT platforms located in these countries (with cross-country comparisons limited by likely differences in database coverage).
Similar to the Jaccard index, but accounting for vast differences in database coverage, we define the Edge Consistency (C E (i,j)) between databases i and j as : Where e i,j) is the number of common edges, and E(i is total number of Edges in database i between genes also present in database j.
Therefore, we also calculated a score that is less sensitive to these differences in database size, the majority score, defined as the number of entities that occurs in at least three out of the five pathway databases as a percentage of their union.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com