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For the differentiation of recurrent tumours from treatment-related changes which is a frequent clinical question, the reported cut-off value for TBRmax was 2.0 in centre A and 2.3 in centre B which might also reflect the difference in data processing in the two centres [12, 25].
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Five years later, Mr. Lévy joined Publicis, also in data processing.
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XL assisted in data processing.
Some additional comparisons can be made by comparing different studies in the literature; differences in data processing between the studies can be controlled for to some degree by asking how well the mRNA abundance changes relate to motifs in the promoters of corresponding genes (de Boer and Hughes 2011).
n.a.: not applicable To account for possible differences in data processing by the different software packages, data from the PBS-IIc were analysed with the ProteinChip Software, version 3.1 (Bio-Rad Labs) as well as with Ciphergen Express™ version 3.0.6.
Other factors which may account for the differences in the two experiments include the use of mRNA from different mouse strains, differences in probeset designs and differences in data processing software.
Differences in data processing (phasing and linewidth) were found to be responsible for the variability in the method.
The differences in data processing between the two centres lead to considerable differences especially for TBRmax, slope, TTP and Tvol.
It remains unclear whether diverging results are caused by the composition of the study population, differences in the technical equipment or differences in data processing or a combination thereof.
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