Sentence examples for difference in checkpoint from inspiring English sources
This difference in checkpoint responses was not due to a reduced rate of DNA replication in control cells, which would lead to a reduced incorporation of cytarabine (Figure 2B).
Accepting Usui and Petrini's assumption, a significant difference in protein abundance during the time of checkpoint induction could explain the different effects of BMH1 and BMH2 deletions.
The difference may be related to TP53 mutation (AAG→ CAG; K132Q) in BT-20 cells 36 since p53 plays critical role in checkpoint regulation.
Shorter checkpoint intervals cause frequent checkpointing, large number of checkpoints thus resulting in much time spent in checkpoint activity, higher disk space required to store checkpoint images.
pombe genes that are involved in checkpoint responses (Fig. 6).
To determine whether the difference in survival conferred by the two different alleles is the result of altered abilities to provide checkpoint function, we tested directly the ability of the mutant proteins to confer checkpoint function upon exposure to UV light or CPT.
One downstream consequence of these differences in p53-linked pathways is the difference in the expression of proteins involved in G2/M DNA damage checkpoint regulation and Table 1, Supplementary Material).
These findings suggest that cell cycle-related gene(s) at the G2 checkpoint might play important roles in the difference in radiosensitivity between these cancers, since the G2-residing cells are normally more sensitive to irradiation.
These observed differences may be due to a difference in kinetochore recruitment or a change in release from spindle poles following checkpoint silencing.
Activated DNA damage checkpoint frequently induce cell cycle arrest or apoptosis, yet we have not observed any difference in regard to apoptosis or proliferation after cytarabine treatment between Ras and control cells.
We found that the apc1 mutant showed only a 1.7-fold difference in centrosome and spindle misorientation (Figure 4C), indicating that the apc1 mutant is partially defective in the centrosome orientation checkpoint.
