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IVF children derived from embryos that were cultured in two different media showed a significant difference in birthweight of almost 250 g (Dumoulin et al., 2010).
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We therefore examined the associations between birthweight and risk markers for type 2 diabetes and CVD at both individual and ethnic group levels in children of South Asian, black African-Caribbean and white European origin in the UK and examined the contribution of ethnic differences in birthweight to ethnic differences in these risk markers.
As the data were not normally distributed, Mann–Whitney U-test showed that the difference in birthweight between infants of depressed and non-depressed infants was statistically significant (median and interquartile range: 3, [2.6 3.3] vs. 3, [2.5 3.1], z = 2.09, P < 0.05).
30 The difference in birthweight centiles remained significant after exclusion of the five twins (P=0.04).
Calculations of the original sample size were made on the basis of finding a difference in birthweight.
To detect a difference in mean birthweight of 100 g between the groups, a sample size of 211 for each group is needed.
There was no difference in the birthweight of patients compared to normals, but length and head circumference were significantly smaller in our patients.
We found a small difference in birthweight between the groups, with a tendency for the children with missing data on gestational age being slightly heavier, though the distribution of birthweight or gestational age did not differ systematically between the two groups.
This corresponds to ∼100 400g difference in birthweight.
Difference in birthweight centiles remained significant (P=0.04) when twins were excluded.
It showed a significant increase in birthweight of 135 grams.
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