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The significant difference between two tissues (P < 0.05) is indicated by the asterisk.
The significant difference between two tissues (P < 0.05) is indicated by asterisk.
When there is a high impedance difference between two tissues, the interface between them will strongly reflect the sound.
The splicing index (SI), defined by Srinivasan K. et al [ 19], was then utilized to evaluate the relative quantity of splicing difference between two tissues.
Define d i, i') = r ij - r i ' j as the difference between two tissues, i and i', in exon j.
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Obviously the greater the difference between two tissue properties the easier it is to distinguish between them.
In this section, we investigate the relationship of spectral variation and expert labeling, including two aspects: (1) the variation of spectra labeled as the same tissue type and (2) the variation of spectral difference between two tissue types.
This method is an extension of our previous model, SplicingModeler, which predicts the significant CAEs that contribute to the splicing differences between two tissues.
Interestingly, 14 CAEs are predicted to be Nova binding sites, and all of them are only significantly regulating the splicing differences between two tissues.
Second, we applied SplicingModeler, a computational tool we previously developed [ 18] to identify putative hexamers whose functional differences between two tissues potentially contribute to the differences in splicing patterns.
All studies conducted so far have been focusing on gene expression differences between two tissues –i.e., skeletal muscle and electric organ- within a species (cross-tissue approach), overlooking possible differences in the same tissue across different species (cross-species approach).
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