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The difference between the subtypes is based mainly on clinical profiles [ 4].
There was no difference between the subtypes regarding the level of macrophage infiltration.
For CPT distraction, CPT impulsivity, and clinical inattention, there was no significant difference between the subtypes and no significant interaction between subtypes and visits in these factors.
The AN group had greater levels of dietary restraint than the HC group (3.02 ± 0.45 vs. 1.0 ± 0.22, P < 0.01), but there were no difference between the subtypes.
Presence of classical TLSs alone or in combination with non-classical TLSs seemed to be associated with better prognosis compared to the presence of only non-classical TLSs, but again, no statistical significant difference between the subtypes was found (P = 0.304; data not shown).
Lastly, the AN group were significantly more anxious than the HC group (13.9 ± 0.83 vs. 4.38 ± 0.61, P < 0.01) and also more depressed than the HC group (10.3 ± 1.23 vs. 1.62 ± 0.39, P < 0.01), but there was no difference between the subtypes.
Similar(54)
The relative lower RI of these predictors compared to cataplexy features may be explained by the fact that they are not unique to the specific subtype of narcolepsy, i.e., patients with NT2 can also have lower PSG sleep efficiency and positive HLA DQB1*06:02, although the statistical differences between the subtypes are significant.
As shown by X-ray crystallography, only subtle structural differences between the subtypes were observed regarding the architecture of their F pockets, including the presence of distinct networks of water molecules.
Yet in all currently reported proteomics CSF studies of MScl patients either only a single subtype of MScl patients or a combined group of all subtypes of MScl was studied, whilst the differences between the subtypes of MScl remained unexplored.
Some differences between the subtypes in clinical features were seen, however, as expected.
Global differences between the subtypes' genomes and recurrent abnormalities at specific loci were identified.
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