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Characterisation of outbreak isolates demonstrated a sequence difference between the outbreak strain and Sabin 1 of 1.1 2.2%, suggesting cVDPV circulation for up to two years prior to detection of the index case, and implying 26 52 "generations" of transmission during this period.
However, alterations in the gene 5 segment cannot explain the emergence of this strain in Central Australia since limited sequence analysis failed to identify any genetic difference between the outbreak and nonoutbreak G9 strains.
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The amino acid differences between the outbreak strains and Rotarix® were analyzed and mapped to the VP7 trimer, identifying several changes in regions of biological function.
For example, the widespread movement of livestock (often over considerable distances) that occurred prior to the detection of foot and mouth disease (FMD) in 2001 resulted in transmission of disease to several spatially distinct foci, one of the main differences between the outbreak of 2001 compared with that of 1967 [ 1].
The difference between the Ebola outbreak and the above crises is that Ebola isn't limited to just Africa.
Antigenic differences were identified between the outbreak G1P[8] strain and Rotarix® in both VP7 and VP4 using N-MAbs, correlating with amino acid changes in known neutralization epitopes.
Early detection can mean the difference between an outbreak and a pandemic.
There were marked epidemiologic differences between the 2 outbreaks, which were separated by 10 years of no epidemic activity.
That's because even if the vaccine was in short supply, allocating it wisely made the difference between a severe outbreak and a mild one.
There was no such difference between both outbreak periods for mixed poultry species IPs and for duck IPs with flock sizes above 500 head of poultry (P > 0.05).
One further difference between the observations of the dengue outbreaks in Yangon from 1984 to 1988 (7 ) and in 2001 was the proportion of dengue patients who had primary infections.
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