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Considering the switching time alone suggests that there is a relatively minor difference between the limited and unlimited scenario.
Since Ctrough is widely used in TDM also, a limited sampling formula (LSF) by means of a linear regression equation of Ctrough vs. FULL AUC24 was calculated to show the difference between the limited sampling formula and a limited sampling model.
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The magnitude of the resulting shift can be estimated from the difference between the limiting RS-score at large γfunc and the neutral expectation of 4.74 without BGC (at functional selection strengths of γfunc < −6 one obtains full conservation at each site).
With the aim to provide sensitive 31P NMR probes of intra- and extracellular pH gradients that may reach cellular acidic compartments in biological systems, new α-aminophosphonates were designed to meet basic requirements such as a low pKas and a great chemical difference (Δδab) between the limiting 31P NMR chemical shifts in acidic (δa) and basic (δb) media.
An explicit form of the approximate solution is developed for cases in which the difference between these limiting eigensolutions is sufficiently small, and an iterative solution scheme is presented for cases in which the difference is larger.
For a single admixture event and for constant ongoing admixture, we characterize the difference between the limit and the mean X-chromosomal admixture under the model as a function of time.
In the Hibbert Lectures for 1882, National Religions and Universal Religions, Kuenen had emphasized the difference between religions limited to a particular people and those that have taken root among many peoples and qualitatively aim at becoming universal.
Souter then noted the difference between a "limited" or bare trust obligation, as was outlined in United States v. Mitchell I (Mitchell I), and those which could impose fiduciary duties and carry monetary damages, as outlined in United States v. Mitchell II Mitchell III).
Here, we determine the number of simulations required for both methods according to the change in difference between the upper limit and lower limit.
If the relative difference (RD%) of the difference between the upper limit and lower limit under a certain number of simulation is less than 5% compared with that under 2000 simulations, the number of simulations tested is taken to be the required number of simulations.
This is preferred to the ordinary least square (OLS) estimator which fails to account for qualitative differences between the limit observations (those with zero WTP) and the non-limit observations (those with WTP > 0), leading to erroneous estimation of the marginal effects [ 17].
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