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The main difference between the intensive and conventional treatment groups was in the use of statins (12).
A recent study in renal transplantation patients did not find any difference between the intensive insulin glycemic group and control patients [ 30].
Quality of life was measured with self-administered multiple choice 46-items specifically for the DCCT, 3 46 but showed no statistically significant difference between the intensive and conventional groups.
It should be noted that in four of the trials the data were presented as the median (interquartile range) [ 10, 11, 16, 26], each with no statistically significant difference between the intensive insulin and control groups.
This approach may have resulted in somewhat lower estimates of absolute mortality risk owing to the relation between hypoglycaemia and mortality, but should not have affected the relative difference between the intensive treatment and standard treatment arms.
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A follow-up of the EDIC cohort 15 years after the study stopped found no significant difference between the intensive- and standard-care groups in terms of cardiac function or remodeling assessed by cardiac magnetic resonance imaging.
In addition to the differences between the intensive glycaemic targets, the conventional target also varied among the trials.
This means that the differences between the intensive histologic workup and the OSNA analysis were because some small tumor infiltrates were localized only in the half of the lymph node that was analyzed either by OSNA or by histology.
Again, there were no significant differences between the intensive and standard glycemic control groups for these items, but any increase in albuminuria was significantly lower (P = 0.05) in the intensive treatment group (17).
In the main VADT outcome results (17), 4.7% of the patients progressed from normal urine albumin to microalbuminuria (which would represent 36 patients in our analysis), and 0.4% progressed from microalbuminuria to macroalbuminuria (representing two patients in our group analyzed), with no significant differences between the intensive and standard glycemic control groups.
The main medication differences between the intensive- and standard-treatment groups were in the former making greater use of repaglinide, rosiglitazone, and basal and bolus insulin and in the latter making greater use of premixed insulin, both in percentage ever prescribed and in the time of use of the medication.
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