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This hypotheses will be tested against the null-hypothesis that there is no difference between the efficacy of methylnaltrexone between the different opioid subtypes.
This study predates by a decade a much larger randomised study which also failed to demonstrate a difference between the efficacy of high-dose interferon-β and that of glatiramer acetate.
There is no statistically significant difference between the efficacy of mannose polymers and GlcNAc polymers.
In conclusion, there was no significant difference between the efficacy of preoxygenation with a BVM or an NRM.
Therefore, most of the studies proved that there was no statistically significant difference between the efficacy of tamoxifen and HDE.
The present study reveals a striking difference between the efficacy of drops and capsules in reaching vitamin D sufficiency in a psychogeriatric nursing home population.
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However, recently presented retrospective data [ 14] and unpublished data from a randomized controlled trial [ 15] suggest a clear difference between the efficacies of the two approaches.
In the present study, we found no evidence to suggest a clinically meaningful difference between the efficacies of a single dose of pegfilgrastim 6 mg or daily filgrastim 5 μg/kg for reducing time to recovery from severe neutropenia – the primary endpoint.
Even after years of clinical research, controversy continues as to whether acupuncture works primarily by the placebo effect, especially given the slight differences between the efficacy of real and sham acupuncture.
Species differences may result in significant differences between the efficacy and, consequently, the safety of the same drug in the various species.
Because Km and Kf depend on the covariance between genotype and phenotype, differences in the genetic determination of traits between the sexes would also translate into differences between the efficacy of selection in males and females.
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