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The reason for this is not clear but in light of previous clinical observations, and the fact that all other investigated cytokines in the present study were more abundantly released from the visceral depot, it is reasonable to assume that the non-significant difference between the depots regarding IL-6 release is due to the relatively small number of observations which limited our power.
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However, neither MCP-1 nor IL-6 release was significantly different between the depots in this population.
There was no significant difference between the mydriasis obtained with the depot system compared with conventional drop application.
There were major differences in B cell content between the depots, ranging from hardly any B cells in gWAT to approximately 35% of the SVF in mWAT of lean mice and approximately 20% of the SVF in mWAT of obese mice (ESM Tables 3 and 4).
No difference between WAT depots were observed in obese subjects.
However, although the expression of CXCR3 expression in SC WAT was slightly lower in T-bet −/− mice compared with WT mice, the difference between the genotypes was not significant in this depot.
In the following 36 125I seeds (34 patients), the average difference between the 125I seed and the centre of the 99mTc-nanocolloid injection depot was 10.9 ± 6.8 mm.
Gene expression data were analysed with a general linear model by means of repeated measures with depot as within variable and animal as between variable, followed by a Bonferroni post hoc test when a significant difference between depots was detected.
It does not make any difference whether the depot is apical or basal.
The only significant difference between the 2 groups was age at baseline, with younger individuals more likely to receive depot antipsychotics.
Thus, as all patients were first stabilized on oral olanzapine and their baseline PANSS scores were within the mildly ill range, the chances of finding differences between the oral and depot formulations of olanzapine were much reduced.
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