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The new 1′-SNic immunogen (2S -N,N′- disulfanediyldiethane-2,1-diyl bis[4- 2-pyridin-3-ylpyrrolidin-1-yl butanamide] conjugated to keyhole limpet hemocyanin (KLH) differed from the existing immunogens 3′-AmNic–rEPA and 6-CMUNic–BSA in linker position, linker composition, conjugation chemistry, and carrier protein.
This action was taken because the contrast of T1WIs obtained in this study might have differed from the existing template and because each scanner introduces specific non-uniformities in image intensity and inhomogeneities in the B0 field.
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