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The expression pattern differed from islet to islet.
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The time course of insulin content per islet differed from that of islet serotonin content, which declined during the last week of pregnancy and during lactation (Fig. 2c).
The period of these oscillation differed from mouse to mouse, but the oscillatory periods were quite similar among islets from the same mouse, which indicates imprinting.
When islets are dispersed into individual beta cells and tissue cultured, they retain the capacity to generate [Ca2+]i oscillations in response to glucose, but the dynamics of these oscillations and their sensitivity to glucose differ from those of intact islets [13] [15].
These data provide clear evidence that NAD(P H oscillations in islets differ from one mouse to the next, as we have observed in other intracellular processes.
Along with the new focus on cell viability was the introduction of a new hypothesis that the responses of human islets to cytokines differ from the responses of rodent islets.
We have previously demonstrated that islet stellate cells (ISCs) exhibiting a similar phenotype to classical pancreatic stellate cells (PSCs) could be isolated from rat islets, where they may contribute to islet fibrosis in type 2 diabetes mellitus (T2DM).
Islet vascularization was linked to islet growth.
Add STZ to islet cultures.
Insulin secretion was normalised to islet equivalents (IEQ), representing islet volume, or normalised to islet insulin content in some samples.
The subspecies P. g. weigandi was not included in this analysis since the habitat of Piperi is expected to differ from that of Skyros and its' surrounding islets and thus not reflect an islet- or mainland habitat effect.
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