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"differ greatly in" is correct and usable in written English.
You can use it when comparing two or more things that have a large difference between them. For example, "The two men's opinions differ greatly in terms of what should be done about the problem."
Exact(58)
NPs modified with different chemistries exhibit diverse biological properties and differ greatly in their adjuvant potentials.
Different precipitation phases (rain, snow or sleet) differ greatly in their hydrological and erosional processes.
Athletics meets differ greatly in presentation.
Organizations differ greatly in their modes of production.
Men and women differ greatly in how they grapple with loneliness.
And those states differ greatly in how much they help their residents pay for higher education.
The two bills differ greatly in the number of people covered and their right to sue.
Its members — violin, viola and cello — evolved in ad hoc fashion, and as a result differ greatly in timbre.
Varieties differ greatly in size, shape, colour, and fibrousness or tenderness of the immature pods.
These complexes differ greatly in their stabilities in solution and in their affinities for the resin.
The national parks of various countries differ greatly in their effectiveness in protecting their resources.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com