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In the next 5 years we will explore the take-home pathways as well as other pathways of pesticide exposure among children, including the dietary pathway.
Recording dietary intake and consumption amounts is an integral part of assessing nutrition and exposures to persistent and nonpersistent chemicals from the dietary pathway.
Food can be an important source of pesticide exposure for children, but most of the studies reviewed here have not devoted substantial resources to an evaluation of the dietary pathway.
Gains of dietary robustness (Fig. 9) can sustain ongoing metabolic elongation only when network structure enables the acquisition of a compound connected to a new dietary pathway in the smallest evolutionary step [ 2, 3, 5] (Fig. 1a).
Dietary phthalate exposure assessment has become a topic of great interest given the significance of the dietary pathway and health impacts associated with the specific phthalate species found in food.
Exploration of a single-reaction radius of dietary entry (scenario 2 in Fig. 8) was commonly associated with stasis or network shrinkage, whereas in 32 out of 33 cases sustained elongation was associated with merging with an additional dietary pathway (scenario 3 in Fig. 8; results in Fig. 9).
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Larger-scale studies that examine manufacturing sources while simultaneously accounting for dietary pathways would be beneficial.
Redundant dietary pathways are those that merge at a common internal node (Fig. 1a).
Metabolic network robustness is thus a central feature of avian carotenoid color elaboration (Fig. 3b and c) and such robustness is accomplished by acquisition of redundant dietary pathways.
Wan, Q. L., Zheng, S. Q., Wu, G. S. & Luo, H. R. Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway.
In a recent study, we demonstrated that hepatic BAF60a serves as a key component of a dietary sensitive pathway that conveys nutritional signals to transcriptional reprogramming to maintain whole body cholesterol homeostasis (Meng et al., 2015).
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