Breast cancer results from genetic and environmental factors including diet, radiation and hormones [ 1- 5].
There is much agreement, however, about the exposures that increase risk, notably tobacco, alcohol, diet, radiation, medications, occupational exposures, general environmental exposures, and infectious agents.
A "bottom-up" approach would focus on each category of external exposure including air, water, diet, radiation, lifestyle, etc. to quantify contaminant levels that would be summed over all categories to estimate individual exposomes.
Statistics collected by epidemiologists attempt to describe and explain the occurrence of disease in a population by correlating factors such as diet, environment, radiation, or cigarette smoking with the incidence and prevalence of disease.
Longevity genes appear to slow down the aging process by making cells and tissues more stress-resistant, better able to withstand the inevitable environmental insults that accumulate over a lifetime from bad diet, inflammation, radiation, genetic mutations and toxic chemical by-products called free radicals.
Environmental factors such as hormones, diet, UV, radiation, and chemicals have causal links to specific human cancers.
Treatment with VE deficiency diet and/or radiation improved the body weight and food intake.
As shown in Figure 8, treatment with VE deficiency diet or radiation downregulated the expression levels of p-PDK1 and p-Akt.
Our results may suggest that all rats treated with VE deficiency in diet or radiation would be in disequilibrium of oxidation and antioxidation, and the even worse situation could exist under the interaction between VE deficiency and radiation exposure.
In this paper we demonstrate that a LS diet and radiation damage increase the amounts of angiotensin converting enzyme, AT II type 1 receptors, TGF-β type1 receptor, collagen IV and OB cadherin in the pericryptal sheaths of descending colon and that the radiation induced effects can be prevented by the ACEI, Captopril.
The other risk factors might be some viruses, bacteria, diet type, radiation exposure, gastroesophageal reflux, occupation, and genetical inheritance [ 2]. H. pylori, a helical shaped gram-negative microaerobic bacterium which was described as a type 1 carcinogen by the International Agency for Research on Cancer Working Group IARC-19944), is related to gastric cancer and MALT lymphoma [ 3, 4].
