Exact(6)
Five major DNA adducts were detected in human lymphocytes treated in vitro with diesel extract.
Gong et al. (2007), which demonstrated that both diesel extract and oxidized lipid components synergistically affect the expression profile of several gene modules related to vascular inflammatory processes.
Multiple matrices were chosen to exemplify a range of complexity including: urban dust, river sediment, diesel extract, and diesel particulate matter (NIST SRMs: 1649b [ 28], 1944 [ 29], 1975 [ 30], and 1650b [ 31], respectively).
The formation of nitrated polycyclic aromatic hydrocarbon (nitrated PAH) DNA adducts, derived from the metabolism of diesel extract constituents, was enhanced relative to other PAH-derived DNA adducts via xanthine oxidase-catalyzed nitroreduction.
A major adduct detected in human lymphocytes treated in vitro with diesel extract comigrated with a major adduct detected in lymphocyte DNA treated with benzo[a]pyrene (BaP) alone.
Other adducts that co-migrated with the major BaP-derived adducts were detected in skin and lung DNA isolated from rodents topically treated with (50 mg) diesel extract and the major adduct detected in calf thymus DNA treated with rat liver S9 and diesel particle extract.
Similar(54)
This means that diesel engines extract more power from their fuel.
It should be noted that the diesel MSM extract only produced dRL2 and mRL2, while the six groups of rhamnolipid were detected in the sunflower oil MSM extracts.
Conversely, the Srf1 group with the shortest fatty acyl residue was detected at the lowest relative abundance in the three water immiscible MSM extracts, however, the diesel MSM extract yielded slightly higher quantities of the Srf1 group compared to the sunflower and kerosene MSM extracts.
Studies have found that diesel exhaust particles (DEPs) are associated with various health effects such as inflammation of the respiratory tract, lung cancer and cardiovascular diseases, and their extracts, diesel particulate extract (DPE), are thought to be mainly responsible for these malignant effects.
In the present study, using Caenorhabditis elegans (C. elegans) as an in vivo system we studied the synergistic effects of diesel particulate extract (DPE) plus UVA, and the underlying mechanisms were dissected genetically using related mutants.
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