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Among 109 patients, 21 have died: causes include 18 due to progressive disease and associated complications (plasma cell leukemia-5, chest infection-3, renal failure-1, sepsis with multi-organ failure-1, myocardial infarction-1).
Thirty-two of 35 patients in the EBRT group died; causes of death included liver failure induced by tumor progression (n = 22, 68.8%), liver failure induced by radiation-induced liver failure (n = 1, 3.1%), distant metastases (lungs or brain) (n = 5, 15.6%), abdominal LN metastases (n = 2, 6.3%), cancer cachexia (n = 2, 6.3%).
Forty-six of 49 patients in the non-EBRT group died; causes of death included liver failure induced by intrahepatic tumor progression (n = 35, 76.1%), distant metastases (lungs or brain) (n = 4, 8.7%), abdominal LN metastases (n = 5, 10.9%), cancer cachexia (n = 1, 2.2%), and unknown cause (n = 1, 2.2%).
Twenty-four oft of thirty-seven relapsed patients (65%) died; causes of death werelapsedr patientsion (n=22) or treatment-related mortality (n=2) (patients died because of septic shock after one dose of topotecan and after one cycle of ICE (ifosfamide, carboplatin and etoposide), respectively).
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