Under normal conditions, algae contribute to the oxygen balance in rivers and also serve as food for fish, but in excessive amounts they crowd out populations of other organisms, overgrow, and finally die owing to the exhaustion of available nutrients and autointoxication.
These results all argue that: (1) The sec8 mutant flies die owing to problems in the nervous system but not the NMJ defects, and (2) all NMJ phenotypes are indeed due to specific disruption of sec8.
In the mouse model, DNA damage induces senescence in lymphoma tissues when the cells 'cannot die' owing to enforced expression of bcl-2, an antiapoptotic factor (Schmitt et al, 2002).
However, these chemotherapies are not fully effective and as a result, 20% of all osteosarcoma patients still die owing to tumour metastasis (Link, 1993; Unni, 1996; Bacci et al, 2006).
In recent years, the idea that tumour cells treated with cytotoxic drugs or radiation die owing to apoptosis (programmed cell death), as opposed to the direct effect of the treatment itself, has become widely accepted (Barry et al, 1990; Reed et al, 1994; Aldridge and Radford, 1998; Ferreira et al, 2002; Jazirehi et al, 2003; Okada and Mak, 2004).
Thus, Vegfa-, Kdr- and Flt1-null mutants die owing to severe vascular defects before overt neuronal differentiation, and Nrp1-null mutants die between E10.5 and E12.5 in the genetic backgrounds available in other laboratories (e.g. Kawasaki et al., 1999; Jones et al., 2008).
Our forests, mountains, and countrysides are dying, owing to a sudden overpopulation of pop stars seeking authenticity.
If such an animal is X-rayed, the proliferation of new cells is inhibited and the hydra gradually shrinks and eventually dies owing to the inexorable demise of cells and the inability to replace them.
For all the reported cases, including our patient, three out of five patients died owing to acute pancreatitis after esophagectomy.
Finally, 12 flaps (85.71%) remained viable, 1 (7.14%) had partially sloughed, and 1 (7.14%) had completely died owing to a hypercoagulable state.
Of the 1610 patients, six died owing to complications, including intestinal perforation, septic shock, tumor rupture, liver failure, and other unknown causes [9].
