Exact(5)
Indeed, PERK inhibition did sensitize cells to death by bortezomib.
The oligomers did not directly encounter the ER, but did sensitize cells for a secondary ER stress insult.
In tumor fragments from five of the tumors, ABT-737 did sensitize the mesothelioma cells to bortezomib-induced apoptosis.
Interestingly, ABT-737 did sensitize the BidYFP-S66A cells to paclitaxel, and apoptosis in these cells was rescued to almost the same level as parental and BidYFP-WT cells.
This background did sensitize the sectoring phenotype of hst3Δ colonies as it did for wild-type colonies (compare the hst3Δ colonies between panels A and B in Figure 7 figure supplement 1), but it had a more variable effect on the frequency of half sectors, which is now discussed in the Results.
Similar(55)
Using the same experimental protocol with rabbits bred in a conventional environment, rabbits sensitized with the P. acnes trigger factor antigen developed more severe and diffuse pulmonary granulomatosis than did sensitized mice.
Still, the Murdoch scandal does sensitize one to broader issues besides hacking, blagging and bribery that go under the banner of tabloidization.
However, histamine does sensitize vagal bronchopulmonary C-fibers' response to capsaicin and mechanical stimulation [ 114].
Finally, efforts should also be made to explore ways to improve collaboration between TBAs and the health-care system through mapping the situation (how many TBAs are there, where are they located, what do they do), sensitizing and training TBAs on facility based post-partum care service use and encouraging referrals.
In conclusion, our research has shown that a cell-permeable fusion protein, sTRAIL FeSOD, selectively sensitized K562 and HL-60 cancer cells to TRAIL-induced apoptosis but did not sensitize normal human hepatocytes (LO2 cells) or T cells.
Stable knockdown of XIAP did not sensitize to ABT737-mediated cell death in either MET cell line, whereas cells were readily sensitized to DL-induced cell death.
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