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Although we did observed a 30% p53(R172H) mice with carcinomas, the number of mice with carcinoma in doubles myrAKT p53(R172H) increased to 80% (Figure 5A), tumors that showed bigger size.
However, we did observed a correlation between grades I and IV in the AJCC category (P=0.05, not shown in Table 2).
Although TRAIL-R1 and R2 were minimally affected by the treatment at the mRNA level (data not shown), we did observed a reduction of c-FLIP expression (Supplementary Figure 3).
We saw almost no tumour growth in these mice, but we did observed a delayed weight loss in some of the mice starting at approximately 8 days after MMC treatment.
Although we did not observe a change over time of the percent recording diabetes anywhere on the death certificate, we did observed a statistically significant trend of increased reporting of diabetes as the underlying cause of death over time, which persisted after adjusting for duration of diabetes at death and age at death.
We did not find consistent changes in the expression of ecdysteroidogenic genes in between LUF-S and LUF-R strains of S. frugiperda that would suggest regulation of ecdysteroid synthesis, but we did observed a lower expression of ecdysteroid-22-kinase.
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However, we did observe a significant difference between CORT and CORT+TAM groups in the proportion of BrdU-positive cells colabeled with NeuN.
In addition, a radon detector close to one of the smaller quakes did not observe high radon levels, although it did observe a radon drop a few days earlier.
We did observe a moderate correlation (Spearman r = 0.413, p = 0.056, Supplementary Fig. 4) between pre-treatment ctDNA levels and tumor burden.
We did observe a decrease in mPaw.
We did observe a small 0.03 increase in BMI z-score from pre- to post-park (p = 0.0007).
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