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However, overexpression of Zfp69 did not induce overt diabetes with hyperglycaemia and beta cell loss.
Our results are consistent with a recent report in which miR-133 loss-of-function mice did not induce overt defects in skeletal muscle [ 24].
As previously reported in a different system (Patry et al, 2003), hnRNP reduction did not induce overt cell death (Fig 5A and Supporting Information Fig S9).
HS did not induce overt liver damage as measured by ALT levels; minor increases were observed by HS+WY treatment in wild-type but not PPARα-null mice at 4 and 24 hrs that approached significance (data not shown).
No mortalities or significant changes to fork length (p = 0.543), body mass (p = 0.439), GSI (p = 0.542), or condition factor (p = 0.940) occurred during the 28-day experiment (data not shown), confirming that the selected exposure concentrations did not induce overt toxicity.
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Previous studies from our laboratory have established that the introduction of sterile agarose beads does not induce overt inflammation or peripheral immune cell infiltrates (Kielian et al., 2001; Baldwin and Kielian, 2004).
Treatment with AEF did not induce any overt signs of toxicity or hepatotoxicity.
Oral treatment of ALE did not induce any overt signs of clinical toxicity or stress in acute or chronic terms.
B [a]P did not induce significant levels of overt death or apoptosis, as assayed by trypan blue exclusion and propidium iodide staining and flow cytometry, under any of the conditions shown in Figure 2 (~7% apoptotic in both vehicle and B [a]P-treated cultures).
We have previously reported that chronic As exposure at similar doses did not induce any histologic changes or overt cell population changes in mouse lung tissue sections (Andrew et al. 2007).
Six weeks of WD feeding caused hepatic steatosis development as evidenced by the 2.25-fold increase in liver triacylglycerol content, but did not induce advanced liver disease (i.e., no overt inflammation or fibrosis) in adult Brown Norway rats.
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CEO of Professional Science Editing for Scientists @ prosciediting.com