Unfortunately, most of these patients succumb to new tumors [2] because cytosine arabinoside does not effectively target the critical tumor progenitor cells, which allows the tumor to reappear over time.
These measures are usually inefficient and do not effectively target the core mechanism of MGD.
Furthermore, these treatment methods have limited efficacy due in part to the fact that they do not effectively target the interaction between tumor cells and bone [ 5].
Further, while tumor cells do not effectively target βcat for destruction, it is less clear at what step destruction is blocked by APC truncation.
Alternatively, because RUNX2 expression correlates with basal-like human disease, it could be that the MMTV-driven expression in the transgenic model does not effectively target the most susceptible cell population.
It is likely that these programs do not effectively target the main factors influencing condom use, including the economic asymmetries, dominant patriarchal socio-cultural practices and resulting power differentials between men and women, all of which may influence the agency of women to actively and effectively negotiate safer sex practices, including condom use [ 7].
The results were disappointing [ 3] with limited therapeutic value, because exogenously administered, unmodified human β-glucocerebrosidase, derived from placenta, did not effectively enter the target cells in the body, due to the lack of exposed mannose residues.
"Nations did not effectively and efficiently share national intelligence and targeting information among allies and with partners," the report said.
