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Liu et al. [ 16] showed that the selective Cox-2 inhibitor NS 398 did not directly effect tumor cell proliferation of PC-3 prostate carcinomas but suppressed tumor growth through a down regulation of VEGF mediated tumor angiogenesis.
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Overall, the findings reveal that IEC plays an important role in strategy formulation and strategy implementation, although it does not directly effect on firm performance.
Our findings correlate well with a recent report that identified CHK1 as being over-expressed in TNBCs and that p53 expression does not directly effect CHK1 expression [ 31] suggesting that CHK1 is a valid TNBC target, distinct from other non-tumor cells.
She concludes with the reflexive disclaimer, "I'm straight, Prop 8 doesn't directly effect me," but her own account points to the slippery slope the same-sex marriage ban and other anti-gay marriage initiatives could send us down.
However, unlike our study, these studies only dealt with immediately acute effects and did not directly examine the effects of natural sunlight.
Our analysis focused on the occurrence of severe outcomes and did not directly consider the effect of vaccination on reducing disease transmission and the resultant downstream effects, such as reduced societal disruption and economic costs (such as those associated with time lost from work or school).
However, our study did not directly evaluate the effect of information on the opinion towards the organ donation law.
Thus, they did not directly predict the effect on protein function, just the extent of free energy change.
Although we did not directly address the effect of chemotherapeutic agents alone on Treg and Th17 frequencies, we observed no significant differences between the patient population treated with monotherapy and those treated in combination with chemotherapy.
Although we did not directly compare the effect on angiogenesis between activin A and TGF- β in vivo, our findings support the inhibitory role of activin A on tumour angiogenesis, unlike TGF- β.
In a minority of mutations, the validation results were either uninformative (N = 36) or the methods did not directly imply an effect on splicing (N = 2); these mutations were therefore excluded in determining the accuracy of predictions (shaded in grey in Supplementary Table 9).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com