The Plp promoter and its regulatory elements, located in exon 1 and intron 1 of the gene, were previously shown to dictate expression specifically to oligodendrocytes [6], [7], [8] and Schwann cells [9], [10] at various stages of development.
Additionally, these qualitative data are consistent with the hypothesis that Gal4 levels dictate expression from the 5XUAS reporters.
These differential androgen receptor/chromatin interactions dictated expression of a distinct gene signature with strong prognostic potential.
A combination of stimulatory signals, including Wnts, Sonic hedgehog (Shh), and Noggin, and suppressive signals, such as BMP4, ultimately dictate expression patterns of the primary MRFs, MyoD1 and Myf5, and therefore propel commitment to the myogenic fate.
This evidence, taken together with the fact that Streptomyces display an unusually high G+C bias and generally do not require a highly conserved ribosome binding (Shine-Dalgarno) sequence for translation initiation [23], might suggest that polypeptide chain elongation during translation plays a crucial role in dictating protein expression.
No significant defect in the activation of NF- κB, a major transcription factor dictating A20 expression, was observed in E1A/Ras-transformed MEFs.
Gametic imprint marks play an essential role in dictating the expression profile to the developing embryo as they are faithfully inherited in the somatic tissues.
Altogether, several credible arguments can be raised that it may not be possible to learn all of the "rules" dictating gene expression outputs, using standard types of statistical analysis and existing data.
Equally intriguing is the finding by Xu et al. that 14-3-3ζ 14-3-3ζ 14-3-3ζistating the expression patterns of additional 14-3-3 family members (e.g., 14-3-3σ), thereby generating an extensive level of capable capable of fine-tuning the context andictatinggical outhet of mexpressionsignals stimulated by TGF-β.
Second, particular differences in expression between CMV::luc and fos::luc mice (the dorsal cranial spot and eye signal) also suggest that luciferin levels did not dictate expression patterns.
