This result strongly suggested that SYT-SSX2 dictated commitment to the neural lineage through its physical recruitment to genes involved in diverse aspects of neural function and growth.
Pituitary development depends on a complex cascade of transcription factors and signaling molecules that dictate organ commitment, cell differentiation and cell proliferation.
Recently, we reported that SYT-SSX2 reprograms mesenchymal stem cells and myoblasts by dictating their commitment to the neural lineage while disrupting their normal differentiation.
The stoichiometry between the pro- and anti-apoptotic Bcl-2 proteins dictates the cellular commitment to apoptosis.
At present, regulation of apoptosis by Bcl-2 family members is complex and not fully understood because most cells express a variety of antiapoptotic and proapoptotic Bcl-2 proteins, and the regulation of their interactions dictates survival or commitment to apoptosis [ 31].
"UNICEF's position is dictated by our commitment to reverse the growing and tragic pattern of victimization of children in today's conflicts, where youngsters are subjected to amputation, systematic abductions, rape and sexual exploitation and abuse, and are attacked in schools and hospitals, terrorized in refugee camps and manipulated as expendable pawns of war," Ms. Bellamy said.
Collectively, these findings provide new insights into how oncogenic mutations might subvert the normal process of lineage commitment and dictate the phenotype of resulting malignancies.
The 28-year had previously hinted the 2016 Rio Olympics would be his last competition but sponsorship commitments dictated he will continue until 2017 where he will focus solely on the 100 meters.
Because of economic constraints and the numerous commitments dictating the life of any academic, the project duration was fixed at 9 days a terribly short time for such an ambitious task.
We found that fiber chemistry dictated cell adhesion while braiding angle dictated the tissue-specific lineage commitment of hiPSC-MSCs.
