The Plp promoter and its regulatory elements, located in exon 1 and intron 1 of the gene, were previously shown to dictate expression specifically to oligodendrocytes [6], [7], [8] and Schwann cells [9], [10] at various stages of development.
Thus, we suggest that ZRE affinity may play a major role in dictating expression patterns observed among Zap1 target genes.
Additionally, these qualitative data are consistent with the hypothesis that Gal4 levels dictate expression from the 5XUAS reporters.
A combination of stimulatory signals, including Wnts, Sonic hedgehog (Shh), and Noggin, and suppressive signals, such as BMP4, ultimately dictate expression patterns of the primary MRFs, MyoD1 and Myf5, and therefore propel commitment to the myogenic fate.
Tissue concentrations of lycopene are likely dictated by expression of and genetic variation in lipoprotein receptors, cholesterol transporters, and carotenoid metabolizing enzymes, thus impacting lycopene accumulation at target sites of action.
Clearly, additional in-depth studies are required to understand the role of individual integrins in the regulation of cytokinesis: their contribution may be dictated by expression level, affinity for available ligands, as well as their ability to promote signaling events required for the successful completion of cytokinesis.
Second, particular differences in expression between CMV::luc and fos::luc mice (the dorsal cranial spot and eye signal) also suggest that luciferin levels did not dictate expression patterns.
Splice order dictates protein expression level, with highest protein expression for the factor in the first position and lower protein expression for the factors in the second and third positions (Wang et al., 2015a).
The disparity between GBM xenograft expression profiles suggested that the orthotopic implantation site can dictate gene expression, presumably due to signaling between the tumor cells and the surrounding stroma.
However, the phases of the peripheral rhythms were significantly clustered with the phase of the activity rhythm, strongly suggesting that signals from the SCN continue to dictate the expression of peripheral phases in wild-type mice despite the expression of FAA behavior.
