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Participants completed a daily diary for the duration of their illness and rated the the severity of their symptoms including cough, shortness of breath, chest pain, and blocked or runny nose.
Subjects also had to be willing and able to return to the study site within 72 h of the first use of study medication; record each attack and each instance of the use of DFN-02 and rescue medication in a patient paper diary for the duration of the study; provide written informed consent; and use the DFN-02 intranasal spray device correctly after instruction.
Participants maintained a diary for the duration of the study period to record concomitant therapies and adverse events (AEs).
Instructions were provided on giving the yogurt and maintaining a diary for the duration of treatment plus 1 week.
All participants will complete a daily diary for the duration of the study, with the diaries collected at the conclusion of each assessment.
Participants will be instructed to perform the exercises daily and record their performances in a training diary for the duration of week 2 of the trial.
Each participant was asked to keep a daily record of bedtime, get-up time, naps, daytime activities and medication in a standardised diary for the duration of actigraphic monitoring.
The diary recorded the duration and severity of 12 symptoms (cough, phlegm, shortness of breath, wheeze, blocked or runny nose, chest pain, muscle aches, headaches, disturbed sleep, general feeling of being unwell, fever and interference with normal activities).
Participants will be instructed to perform the exercises daily and record the exercises they completed and their difficulty level in a training diary for the duration of week 2 of the trial.
