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Patients were tested for C. difficile if they had diarrhoea (defined as ≥3 bowel movements in 24 hours) or a temperature of ≥38.6°C and white cell count ≥20 x 109/mL.
Diarrhoea, defined as three or more loose stools on a given day, will trigger impact diary completion.
Severe vomiting, defined as = three times in the 24 hours prior to inclusion in the trial or inability to tolerate oral treatment, or severe diarrhoea defined as ≥ three watery stools per day.
Recent reports show that diarrhoea, defined as the passage of three or more loose or liquid stools per day, is one of the leading causes of morbidity and mortality in children under 5 years old (1, 2).
Active surveillance was carried out continuously in the emergency department and inpatient wards in children under 5 with acute diarrhoea, defined as three or more loose stools in a 24 hour period and with onset less than 14 days before the hospital visit.
Outcome measures were infant illness episodes since birth as reported by the mother at the 2 months postnatal time-point: (1) diarrhoea: defined as three or more loose or fluid stools in a 24 h period, (2) ARI: defined as cough with associated difficulty breathing, and (3) fever.
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A quantitative score based on stool volume and consistency was used for daily assessment of diarrhoea; diarrhoea was defined as a score ≥15.
Persistent diarrhoea was defined as diarrhoea for 14 days or more.
Community-acquired diarrhoea was defined as diarrhoea, which developed before 48 hours of admission.
Hospital acquired diarrhoea was defined as diarrhoea which developed ≥48 hours after admission.
An episode of acute diarrhoea was defined as diarrhoea with duration between 24 hours and less than 14 days.
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CEO of Professional Science Editing for Scientists @ prosciediting.com