Sentence examples for diaphragm integrity from inspiring English sources

Due to the increased expression of podocyte-related nephrin and podocin proteins, astragaloside maintained slit diaphragm integrity and decreased the level of proteinuria in rats with adriamycin nephropathy.

PHN is a rat model of human membranous nephropathy associated with altered podocyte slit diaphragm integrity, sub-epithelial immune deposits and expansion of glomerular basal membranes [43], [44].

Altogether, these observations indicate that aPKCλ is necessary for the maintenance of slit diaphragm integrity and apico-basal cell polarity in podocytes.

Thus, we suggest that PAN inhibits the transcription of CD2AP mRNA and decreases the synthesis of CD2AP protein, which leads to inadequate CD2AP in the slit diagram, impairing diaphragm integrity and normal binding between CD2AP and p85.

Whaley-Connell et al. demonstrated that increases in kidney cortical tissue ANG II, AT1R, and total NADPH oxidase activity submits (NOX2, p67phox, p47phox, and Rac1) expression, ROS production, podocyte effacement, and loss of the slit-pore diaphragm integrity in Ren2 rats compared with age-matched Sprague-Dawley (S-D) rats [ 39, 42].

One important functional feature of EOM is that they are to be considered as tonically active muscles such as the diaphragm where function integrity depends upon the sufficient availability of antioxidant substances such as Se and SOD [ 129].

DEX can increase the transcription of CD2AP and the expression of proteins and promote localization to the slit diaphragm, thus maintaining the integrity of the SD.

Moreover, actin will dissociate from nephrin (the key component of the slit diaphragm), altering the functional integrity of the glomerular filtration barrier.

This would support the role for nephrin as a structural sensor regulating the integrity of the slit diaphragm.

Specifically in the diabetic millieu PKCα mediates nephrin endocytosis and PKCα-deficiency or inhibition leads to preserved nephrin expression on the podocyte surface and thus has a direct protective effect on the integrity of the slit diaphragm.

THI treatment in uninjured mdx mice resulted in decreased diaphragm fibrosis and increased sarcomere structural integrity.