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Others, mostly expressed by a nephrotic syndrome, will be considered as idiopathic until the offending factor(s) that affect the molecular array of the slit diaphragm filtration barrier are identified and counteracted.
Similar(59)
10.7554/eLife.07405.027 Figure 4. Vertebrate slit-diaphragm components are expressed in planarian flame cells and are required for the maintenance of their filtration diaphragm.
Inset shows high magnification of filtration diaphragm.
Inset shows a high magnification of filtration diaphragm.
Inset shows a high magnification of the filtration diaphragm.
DOI: http://dx.doi.org/10.7554/eLife.07405.029 10.7554/eLiFigure05.030 Figure 4 figure supplement 3. NPHS1-6 is required for de novo formation of filtration diaphragm during regeneneration.
Under RNAi knockdown of either NPHS1-6 or NEPH-3, the filtration diaphragm was completely absent and the foot processes underwent apparent effacement in both intact and regenerating animals.
Finally, we evaluated the expression of nephrin, which is the principal protein involved in the formation of slit diaphragm in the filtration barrier [ 43, 44].
In the same way, nephrin is the principal protein involved in the formation of slit diaphragm of the filtration barrier [ 43, 44, 58, 59].
DOI: http://dx.doi.org/10.7554/eLife.07405.030 Because flame cell numbers appeared normal in both intact and regenerating animals, we examined the ultrastructure of the filtration diaphragm in NPHS1-6 aNEPH-3 RNAiNAi) NEPH-3 RNAi
These similarities make it tempting to speculate that nephrocytes and podocytes are homologous cell types; a hypothesis that would be strengthened if the filtration diaphragms of other excretory organs, such as the flame bulb filtration slits in flatworms or the end sac filtration cells in arthropod segmental organs, were also based around an orthologous Ig domain molecular complex.
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