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The thickness and diameter of tablets (n = 5) with each formulation were measured using Vernier Calipers.
F1 showed Hixson Crowell as best fit model which indicated the constant release from the system where there is a change in surface area and diameter of tablets.
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The weight and diameter of the tablets were designed to be about 300 mg and 10 mm, respectively.
The diameter of the tablets was 6 mm.
The thickness and diameter of the tablets increased when exposed to thermal treatment, which could be caused by the formation of the wax matrix when the wax melted.
A plot of gray values across the diameter of each tablet was determined from a digital photograph taken with the CD-3.
NIR transmission was also shown to traverse a wide section of the tablet by comparing relative blocking intensities from different regions of the tablet surface and >90% of the signal was detected through a central area of 7 mm diameters of the tablet surface.
About 24,500 of these objects are larger than a centimeter, about the diameter of an aspirin tablet, and could cause catastrophic damage to the space station upon impact, it said.
However, it is interesting and promising to mention that, it took less than a minute (c.a. 53 s) to scan an area of 6 mm × 6 mm considering the tablets' diameter of 9 mm.
Interestingly, at the larger tablet diameter of 15 mm, while hardness increased and porosity decreased with an increase in CF, the DT was resistant to change.
A two factor, three level (32) face centred, central composite design (CCD) was applied to investigate the main and interaction effects of tablet diameter and compression force (CF) on hardness, disintegration time (DT) and porosity of mannitol based orodispersible tablets (ODTs).
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