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We worked out and applied a three-compartment dialysis model to separately determine the rate of drug diffusion through the liposomal membrane.
We developed an experimental chronic peritoneal dialysis model for repeated dwell study in rats.
(Table 3) The c-statistics for the chronic dialysis model using the cause-specific Cox approach was 0.66 (95% CI 0.62-0.71).
Multiple measures including dietary phosphorus restriction, oral phosphorus binders including non-containing calcium phosphorus binders and dialysis model should be optimized to improving the control of hyperphosphatemia, which in turn may reduce the risk for vascular calcification and cardiovascular mortality.
For the first time, we described an experimental chronic peritoneal dialysis model with repeated dwell studies with drainage in nonuremic rats and evaluated the effects of addition of heparin to glucose-based peritoneal dialysis fluid on peritoneal fluid and solute transport [ 3].
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The purpose of this study was to characterize the rotating dialysis cell model with respect to basic model and drug related factors affecting the rate of drug appearance in the acceptor phase after initial instillation of the solutes into the donor cell.
Model-1 was adjusted for age and gender; Model-2 was Model-1 plus adjustments for co-morbidities associated with survival during the previous step; Model-3 was Model-1 plus adjustments for mobility; model-4 was Model-1 plus adjustments for initial condition at the start of dialysis; and Model 5 included all variables used in the other models.
The characteristics of the rotating dialysis cell model suggest that it may be a useful tool in the design of innovative depot injectables in the area of local joint delivery.
The correlations obtained in this study hold promise that the rotating dialysis cell model has a role in the prediction of the intra-articular fate of drugs injected as solutions.
Among patients requiring chronic renal dialysis, this model had discrimination and fit statistics as follows: area under the ROC curve 0.817 955% CI 0.802 to 0.832), B = 0.173 and R = 0.595.
This chronic peritoneal dialysis rat model allows us to examine also the influence of different substances exemplified by GDPs on changes in renal function and kidney structure in a case of reduced number of nephrons [ 38] and to achieve a background very similar to the clinical setting in patients treated with peritoneal dialysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com