Furthermore, TP53 mutation analysis of the diagnostic samples of eight relapsed patients did not show any mutations.
The coded diagnostic sample of the patient's blood obtained on July 22 , 2013was received at RML 3 days later.
In conclusion, this pilot proteomics study suggests that tumor expression of ANXA2 in diagnostic samples of a PCa may be predictive for the metastatic potential of that cancer.
Thus, we analyzed E2F7 expression levels in human monocytes isolated from healthy donors and diagnostic samples of AML patients by real-time RT-PCR.
In addition, lincRNAs are also detectible in body fluids such as plasma and urine [ 48- 50], diagnostic samples of which are easy to collect using noninvasive methods.
We compared the frequency of cells with immunophenotype of myeloid DC (mDC: Lin−, HLA-DR+, CD11c+, CD86+) and plasmacytoid DC (pDC: Lin−, HLA-DR+, CD123+, CD86+) in diagnostic samples of 47 FLT3-ITD− and 40 FLT3-ITD+ AML patients.
In addition, MLPA analysis of 22 diagnostic samples of BCP-ALL with TCF3-PBX1 in the independent CCLSG cohort identified one patient with IKZF1 deletion who eventually relapsed and died.
Importantly, in the first diagnostic sample of this patient still showing a normal karyotype, the ETV6 mutation was present, indicating that this mutation emerged early in the course of the disease.
TP53 mutation has been associated with relapse in BCP-ALL patients with TCF3-PBX1 fusion 8. Therefore, we screened for mutations in TP53 in the diagnostic samples of eight cases experiencing relapse.
To evaluate the importance of CEBPA-mediated miR-29b induction in vivo, we analysed miR-29b expression in diagnostic samples of 66 AML patients, three samples of enriched CD34+ myeloid stem cells, and in samples of mature granulocytes and monocytes from 6 healthy volunteers.
