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To comprehensively define the clinico-pathologic features of these newly recognized molecular entities, we first tested the diagnostic robustness of the C19MC and LIN28 markers in a spectrum of pediatric brain tumors for which materials were available for central re-review of histopathology and confirmation of histologic diagnosis according to the current WHO CNS tumor classification criteria.
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It is possible that by including patient clinical symptoms or results from other tests, diagnostic accuracy and robustness could be further improved.
In a nutshell, while the diagnostic process requires robustness and flexibility to deal with the uncertainty of not knowing or not knowing enough, physicians remain not trained nor do they tolerate uncertainty hence committing mistakes.
The developed model has the potential to enhance the design of optimization-control techniques for fuel consumption benefits and on-board diagnostics health measurement robustness.
Lateral flow biosensors (LFBs) are paper-based devices which permit the performance of low-cost and fast diagnostics with good robustness, specificity, sensitivity and low limits of detection.
Our results show that PLNPs are a promising class of materials for LFAs and potentially other in vitro diagnostics applications requiring robustness and high sensitivity.
Of note, the relative robustness of diagnostic accuracy against AC-related errors as observed in this present FDG brain PET study cannot simply be translated to other PET tracers or to other body regions without further investigation.
Kohlmann et al (2005) demonstrated that preparation by different operators and use of different sample-handling procedures did not impair the robustness of diagnostic gene expression signatures.
In the subsequent validation step, targeted measurement of the elucidated potential biomarkers is applied to a large sample set to study the diagnostic power (sensitivity, specificity, robustness, etc).
After running 'crunch' and 'brunch', the 'caic.diagnostics' function in 'caper' carried out diagnostic tests for the robustness of contrasts and identified the outlier contrasts that had absolute studentised residuals greater than three.
Moreover a sliding window scheme combined with a simple majority voting filter further increases the reliability and robustness of the diagnostic method.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com