In this Personal View, we outline key areas for clinical, diagnostic, and operational research on this disease in Africa and propose a research agenda that aims to advance the management of Buruli ulcer in Africa.
"Major new investments in drug development, diagnostics, and operational research are needed.
Helen Counihan, public health specialist, Malaria Consortium, London, UK. @fightingmalaria Helen specialises in community health service delivery, diagnostics and operational research.
The ICHD is based on the same principles as the 1st edition, but the term "operational diagnostic criteria" has been replaced by "explicit diagnostic criteria", as the term "operational" is not generally known.
Current operational diagnostic systems have substantial limitations for lifetime diagnostic classification of bipolar spectrum disorders.
The strength of our strategy is the combination of operational diagnostic criteria (ICD-10) and Leonhard's categorical diagnostic approach.
The strength of our strategy is the combination of an operational diagnostic approach with ICD-10 and Leonhard's categorical diagnostic approach maximizing homogeneous subgroups, though reducing power of the sample size.
To assess the psychometric validity (see Statistical analysis section) of the NNIPPS operational diagnostic criteria, investigators were required to assign at entry a diagnostic probability (PSP or MSA) for each patient using two 100 mm-visual analogue scales (VAS).
Martínez-Llordella, M. et al. Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients.
The high-resolution diagnostic is now operational with 32 channels separated by <1 cm and a frequency response of 1 MHz, measuring Te on the low field side, for typical machine operation at BT=5.4 T. We describe the operation of the radiometer based on two novel second harmonic mixers appropriate for these high frequencies.
Other recommendations are migraine-specific, such as operational diagnostic criteria and primary efficacy measure.
