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Histological specimens were subjected to a second review by a qualified pathologist (R. A). for final diagnostic designation.
Non-diagnostic designations (n = 17) were considered neither positive nor negative, and the results were excluded from the analysis.
When one reads Virginia Woolf's "Mrs. Dalloway, James Baldwinn's "Giovanni's Room," Jeanette Winterson's "Written on the Body," or even a work generically encoded as "lesbian," like Patricia Highsmith's "Price of Salt," as "gay" texts, this designation derives from diagnostic practices that readers bring to the texts rather than from the texts themselves.
The presence of brain invasion is a feature considered to predict aggressive clinical behavior and recurrence, and is more recently used as a diagnostic criterion for WHO grade II designation [ 39].
Nevertheless, few studies have examined the prevalence of retinopathy across the spectrum of A1C levels, which could assist in the designation of ideal A1C diagnostic cut points (2, 3).
Pritchardia lanaiensis and P. elliptica were recently synonymized into P. glabrata [ 29], yet our results are inconsistent with this designation because of the diagnostic grouping of all P. glabrata sensu stricto individuals in PAA (Additional file 2).
This is followed by a lowercase letter designating the order of publication, and a numerical designation indicating the number of diagnostic sites that differentiate it from the subfamily consensus.
However, if designation of a tumor to a specific diagnostic category conveys sufficient information, grading is not necessary 4, 5. Histologic reporting of ovarian carcinomas has traditionally required assessment of both cell type and grade.
Comments for each SPRED1 variant often contain additional information or evidence to support the classification designation and whether the patient meets NIH diagnostic criteria for a clinical diagnosis of NF1.
Evaluation was limited to a simple designation of: acceptable or not acceptable (i.e. diagnostic, or non-diagnostic).
However, for most of the molecular changes this does not justify a designation as glioma biomarker, because biomarkers should provide unique diagnostic, prognostic, or predictive information exceeding that reached by mere histological classification.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com