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However, the less stringent phenotypes that we identified do appear to be on the same diagnostic continuum as the full diagnosis (in terms of having similar symptom profiles and sociodemographic associations).
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Our data suggest that cerebral palsy is on a diagnostic and genetic continuum with intellectual disability, disorders of motor development and possibly autistic spectrum disorder, with these latter conditions already known to be caused by de novo mutations.
Physicians practicing in limited-resource settings, especially in the absence of alternative imaging capabilities, may be compelled to consider such novel use of ultrasound without strong evidence, realizing that images obtained from a particular patient may be anywhere in the continuum of diagnostic confidence from non-diagnostic to specific beyond any doubt.
Thus, the study will specifically refer to the terms "FAS" or "FAE", acknowledging that these 2 terms are diagnostic categories within the continuum of the broader category of "Fetal Alcohol Spectrum Disorder".
Table 1 International Headache Society diagnostic criteria for hemicrania continua Description: persistent strictly unilateral headache responsive to indomethacin Diagnostic criteria A.
Most of remotely sensed spectra are composed of mixtures and not necessarily pure materials, and then the spectral reflectance curves produce a continuum upon which diagnostic absorptions may be superimposed.
We then explored similar mediation and moderation hypotheses across the colon cancer care continuum: thoroughness of diagnostic investigation, stage of disease at diagnosis, receipt of and wait times for surgery and adjuvant chemotherapy, and receipt of palliative care.
These diagnostic products are used throughout the continuum of medical care and span a broad range of applications from risk assessment and diagnosis of disease to monitoring progression and management of health conditions.
These results show that there is much diagnostic delay that deters the POC continuum.
Because the present study sought to operationalize fear on a continuum rather than for diagnostic purposes, the 10 items were summed to form a single score (α = .83).83
Children with more moderate phenotypes along the FASD continuum represent a real diagnostic challenge, with an estimated incidence of 1 per 100 live births in Western countries.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com