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The rhabdomyoblast is the diagnostic cell in all types which shows granular eosinophilic cytoplasm with thick and thin filaments.
The biosensor is specific for Tdp1 even in complex biological samples, such as human cell extracts, and may consequently find future use in fundamental studies as well as a cancer predictive tool allowing fast analyses of diagnostic cell samples such as biopsies.
For the time being, the method produces one diagnostic cell type (squamous intermediate) and four levels of debris.
In the near future, it may also become possible to broadly offer noninvasive diagnostic cell free fetal DNA testing through maternal serum [ 22].
Until the cell block preparation method is optimized, the responsibility of collecting enough material for a diagnostic cell block remains with the endoscopist.
Recently, human cardioviruses (hCVs) were identified in archived diagnostic cell culture supernatants (4 ) and in clinical samples from children with diarrhea or respiratory infection (5, 6 ).
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Commonly employed targeting groups include folate-capped lipids that have a preference for rapidly dividing cells overexpressing the folate transporter, and glycolipids that are selective for diagnostic cell-surface lectins on cancer cells.
To determine if a spatula plus an EC brush increased recovery of diagnostic cells over the SurePath broom, ectocervical spatulas from Rovers and Medscand were examined.
Excess blood and inflammatory cells are lysed, and approximately 50,000 diagnostic cells are randomly transferred by the equipment as a thin layer onto a glass slide by a robotic cell processor.
This can be explained by the presence of a thick keratin layer that covers the vulvar epithelium, which requires vigorous brushing to obtain the underlying diagnostic cells for adequate sampling.
Approximately two-thirds of false-negative smears were related to sampling errors, and the remaining third were due to screening and/or interpretative errors, mainly due to the small number of diagnostic cells present in a suboptimal smear (Vassilakos, 1998b).
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