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The HCs were included to examine the diagnosis specificity of each of the FMS patterns.
For highly sensitive screening, a lower OD index ≤0.5 is preferable, whereas to provide accurate diagnosis, specificity can be improved with a higher OD index of 1.5.
A PVPI value of 2.6 to 2.85 provided a definitive diagnosis of ALI/ARDS (specificity, 0.90 to 0.95), and a value < 1.7 ruled out an ALI/ARDS diagnosis (specificity, 0.95).
Therefore, if acute-phase IgM had been used to diagnose acute leptospirosis instead of paired serum specimens, only 21 of 120 acute infections would have been identified (sensitivity 17.5%, 95%CI11.2%25.55.5%), and 201 of 653 patients without acute leptospirosis would have been given an erroneous diagnosis (specificity 69.2%, 95%CI65.5%5%–72.7%).
Mitchell (2007) reviewed 38 studies examining ultra-short PROMs for distress, and found that these tools were very good at excluding possible cases of depression (sensitivity 78%, negative predictive value 93%), but were poor at ruling in a suspected diagnosis (specificity 67%, positive predictive value 34%).
The fact that the scores of cases meeting the Canadian criteria were consistently lower than those not meeting the criteria further suggests that diagnosis specificity is related to disease severity, and that diagnostic criteria such as the Canadian may be more appropriate for research studies investigating risk factors and disease biomarkers.
Similar(54)
This data analysis proved highly specific for diagnosis (100% specificity in the final validation set), provided those with visible blood contamination were excluded from analysis; 6 8% of samples were classified as indeterminate.
Bacteriological culture is the reference test for TB diagnosis, as specificity is 100% [1], [8]; nevertheless false negative results do occur [19].
When only those epilepsy patients without IEDs were considered (n = 74), theta band SL could predict diagnosis with specificity of 76% and sensitivity of 62%.
BHR only identified 50% of those with a GP diagnosis; the specificity was also relatively low (75%).
The first search utilized the Clinical Queries tool, using the term "cirrhosis", and the options "diagnosis" and "specificity".
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