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Although it could be argued that exclusion of rare diagnoses reduces the fidelity and realism of the synthetic data, a data set without the particular rare diagnoses that were excluded is not unrealistic.
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The only discharges that were excluded were the small number of hospital episodes that lacked discharge diagnoses.
Those that exclude need those that are excluded to be excluded to define them.
Other differential diagnoses that were considered and therefore excluded were Wegener's granulomatosis, giant cell arteritis, Behçet disease, sarcoidosis, neoplastic disorders and systemic infectious diseases.
We excluded diagnoses that were detected incidentally at autopsy, individuals aged less than 20 at diagnosis or if the date of diagnosis was recorded to be after the date of death.
(That's excluding writeoffs).
Rare diagnoses, diagnoses that are unusual in this age group, and diagnoses that included multiple congenital conditions were excluded from consideration because an individual could be identified from such a diagnosis together with knowledge of the particular region.
Distinction among CD30+ LPD and borderline cases can be challenging; thus patients were carefully selected so that borderline diagnoses were excluded.
Nine patients died the same day that they were diagnosed so were excluded from follow up, leaving 1314 cases for analysis.
Further, physicians assigned only one diagnosis per patient visit, which meant that secondary or other subsequent diagnoses were excluded.
Discharges that included the PE or DVT codes as primary discharge diagnoses were excluded.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com