Subjects were eligible if they were ≥50 years of age, sedentary (≤2 exercise sessions/week), ambulatory without assistance, and had stable type 2 diabetes, defined as no change in diabetic medications for at least 3 months prior to study entry.
Among them, 332 with Type 1 diabetes defined as acute presentation with diabetic ketoacidosis, heavy ketonuria (>3+) or continuous requirement of insulin within 1 year of diagnosis, and 5 with uncertain type 1 diabetes status, were excluded from the analysis.
Among them, 332 with Type 1 diabetes defined as acute presentation with diabetic ketoacidosis, heavy ketonuria (>3+) or continuous requirement of insulin within 1 year of diagnosis [ 14], and 5 with uncertain type 1 diabetes status, were excluded from the analysis.
Introduction: Diabetic ketoacidosis is an acute complication of diabetes, defined as metabolic acidosis with a high anionic gap, associating hyperglycemia > 16 mmol l (3 g l), positive ketonuria, or superior or equal ketonuria to ++, it is a medical emergency which can occur in a known diabetic patient, or not.
Participants included ten men with more than 2 years known duration of type 2 diabetes, defined as diabetes diagnosed after adolescence, and eleven non-diabetic men matched according to age (Table 1).
Among the patients, a number of 304 had a prepubertal onset of diabetes defined as an onset age less than 11.7 years in girls and 12.9 years in boys.
However, recent observational data suggest that in patients with pre-existing poorly controlled type 2 diabetes (defined as an HbA1c ≥7%) prior to their acute illness, targeting glucose concentrations < 10mmol/l is associated with harm [1].
Eligible participants were at risk for diabetes, defined as not meeting criteria for diabetes but meeting at least two 2010 ADA glycemic criteria for prediabetes: fasting plasma glucose (FPG) 100-125 mg/dL, 2-h postload glucose (2hPG) after a 75-g oral glucose load 140-199 mg/dL, and/or a hemoglobin A1c (HbA1c) 5.7-6.4 5.7-6.4 mmol/mol).
Diabetes defined as self-reported or hemoglobin A1c (A1c) ≥ 6.5%.
The primary end point was the development of diabetes defined as hospitalization with a diagnosis of type 2 diabetes.
