In spite of concentrated efforts devoted to decipher the mechanisms underlying CSC chemoresistance and to design targeted therapeutics to these cells, proteomics has failed to unveil molecular signatures capable of distinguishing between malignant and non-malignant stem cells.
In this review, we provide a summary of proteomic and bioinformatic approaches devoted to decipher the bacterial cell-envelope-related proteome and the myriad of physical interactions among its many components, using E. coli as a reference model.
Despite the fact that this apparent dichotomy of APP-dependent biologic effects was proposed several years ago, the overwhelming part of existing experimental work has been devoted to decipher the pathophysiologic, neurotoxic roles of APP.
Extensive efforts have been devoted to deciphering virus infection pathways, and several reports have indicated that the viruses move along microtubules from the cell periphery to the perinuclear region in a rapid and unidirectional way.
In the closing days of the Second World War, William and Elizebeth Friedman gathered a group of experts awaiting demobilization, and together they devoted an enormous amount of time to deciphering the Voynich.
But since 200 pounds of ancient bone and ash were packed in acid-free paper, sealed in bubble wrap and shipped in a custom-built box from Greece last summer, Dr. Agelarakis has devoted 12 to 14 hours a day to deciphering the secrets of 200 to 250 ancient Athenian warriors who probably died in battle at the beginning of the Peloponnesian War.
On a recent evening, a Detroit television station, WXYZ, devoted several minutes to trying to decipher the dueling claims, right down to a discussion of co-payment fees.
("Every statement is either true or false, and no statement is both!") Now, as a physicist at a well-known university, he devotes his days and nights to trying to decipher the hidden rules of the universe.
The opportunity to decipher the mechanisms underlying cellular physiology from the analysis of molecular interaction networks has prompted the establishment of databases devoted to the collection of such data, with great attention to protein and genetic interactions (19 22).
