I would dare to say that if the leaders who showed us the way in the '80s were alive today, they would recommend that we devote major efforts to high technology as the only alternative for the future.
All developed countries are facing a sustained shift in the demographic composition of their population and are thus devoting major effort to increasing the work participation rate of aging and disabled people [ 1].
As president he continued the economic policies of his predecessor, Carlos Salinas de Gortari, but devoted a major effort to restoring public confidence, which was so badly damaged by the scandals of the Salinas administration.
In this specific situation, the Japanese PES does not need to devote a major effort to activation since the unemployed have strong work incentives.
Looking at the future of humanity, major efforts are devoted to finding pathways for sustainable development.
To counteract the potential of competitive fragmentation between disciplines and organizations, major efforts were devoted to openness, transparency and dialogue in the second type of partnerships, actively promoting construction of collaborative methods and strategies based on a set of common objectives.
Thus, major efforts have been devoted to the development of advanced instrumentations capable of addressing these issues (Bohndiek et al. 2013; Garai et al. 2015; Kang et al. 2016; Karabeber et al. 2014; Mallia et al. 2015; McVeigh et al. 2013; Mohs et al. 2010; Wang et al. 2016; Zavaleta et al. 2013).
The high biological relevance of the latter modified bases explains why major efforts have been devoted to the design of a broad range of assays aimed at measuring globally or at the single base resolution, 5-hydroxymethylcytosine and the two other oxidation products in the DNA of cells and tissues.
Major efforts have been devoted to understand the molecular mechanisms governing HA binding specificities by determining crystal structures of HA-receptor complexes and analyzing HA-glycan binding using glycan arrays [8], [9], [10], [11], [12], [13], [14], [15], [16], [17].
